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| CANTAB - Decision making and response control tests |
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To
view all CANTAB tests, click here [open/close]
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| These tests add another dimension to cognitive profiling and investigation of frontal lobe function. Most decisions in life have an emotional or risk related component, and many clinical conditions are associated with inappropriate risk models/strategies. |
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AGN (Affective
Go/No-go)
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Overview
This test assesses information processing biases
for positive and negative stimuli.
Affective cognitive functions are thought to be
related to the ventral and medial-prefrontal cortex
areas of the brain because of the limbic connections
with this region. As such, the Affective Go/No-go
test represents a powerful research assessment tool
for current studies on the neural substrates of
depression, bipolar disorder, Post-Traumatic Stress
Disorder (PTSD) and many other affective conditions.
Murphy
et al, 1999 , found that manic patients had
a clear bias for positive words (because they showed
less inhibition in moving from negative words as
targets to positive words as targets) while those
in the depressed state had a bias for negative words.
Making a decision about the emotional valence of
a wor d is associated with the cingulate gyrus (Elliott
et al, 2000) . |
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Administration time
Around 10 minutes, depending on level of impairment.
Task
The test consists of several blocks, each of which
presents a series of words from two of three different
Affective categories: Positive (for example, joyful),
Negative (for example, hopeless), and Neutral
(for example, element). The subject is given a
target category, and is asked to press the press
pad when they see a word matching this category.
Test modes
Six modes, four using positive and negative stimuli
only, and two using positive, negative and neutral
stimuli.
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Outcome measures
Twelve outcome measures covering latency and
errors of commission and omission.
Note
Currently available in English only
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CGT (Cambridge
Gambling Task)
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Overview
The Cambridge Gambling Task was developed to assess
decision-making and risk-taking behaviour outside
a learning context. Relevant information is presented
to the subjects 'up-front' and there is no need
to learn or retrieve information over consecutive
trials.
Unlike other 'Gambling' tasks, CGT dissociates risk
taking from impulsivity, because in the ascending
bet condition the subject who wants to make a risky
bet has to wait patiently for it to appear. (Manes
et al, 2002) The likely neural substrate for
this task is the orbitofrontal prefrontal cortex.
Traumatic Brain Injury, Alcoholism and Drug abuse
are all conditions sensitive to this test. |
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Administration time
Up to 30 minutes.
Task
On each trial, the subject is presented with a
row of ten boxes across the top of the screen,
some of which are red and some of which are blue.
At the bottom of the screen are rectangles containing
the words Red and Blue.
The subject must guess whether a yellow token
is hidden in a red box or a blue box.
In the gambling stages, subjects start with a
number of points, displayed on the screen, and
can select a proportion of these points, displayed
in either rising or falling order, in a second
box on the screen, to gamble on their confidence
in this judgement. A stake box on the screen displays
the current amount of the bet. The subject must
try to accumulate as many points as possible.
Test modes
Ascending first (where stakes are displayed in
ascending order for two stages, then in descending
order for two stages) and Descending first (where
stakes are displayed in descending order for two
stages, then in ascending order for two stages).
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Outcome measures
The six CGT outcome measures cover risk taking,
quality of decision making, deliberation time, risk
adjustment, delay aversion and overall proportion
bet. |
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IST (Information
Sampling Task)
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Overview
The Information Sampling Task (IST) tests impulsivity
and decision making. |
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Administration time
Up to 15 minutes
Task
The subject is presented with a 5x5 array of grey
boxes on the screen, and two larger coloured panels
below these boxes. The subject is instructed that
they are playing a game for points, which they
can win by making a correct decision about which
colour is in the majority under the grey boxes.
They must touch the grey boxes one at a time,
which open up to reveal one of the two colours
shown at the bottom of the screen. Once a box
has been touched, it remains open. When the subject
has made their decision about which colour is
in the majority, they must touch the panel of
that colour at the bottom of the screen to indicate
their choice. After the subject has indicated
their choice, all the remaining grey boxes on
the screen reveal their colours and a message
is displayed to inform the subject whether or
not they were correct. The colours change from
trial to trial.
There are two conditions the fixed win
condition, in which the subject is awarded 100
points for a correct decision regardless of the
number of boxes opened, and the decreasing win
condition, in which the number of points that
can be won for a correct decision starts at 250
and decreases by 10 points for every box touched.
In either condition an incorrect decision costs
100 points.
Test modes
IST has two modes:
- Fixed win-decreasing win (after practice trials,
the fixed win stage precedes the decreasing
win stage)
- Decreasing win-fixed win (after practice trials,
the decreasing win stage precedes the fixed
win stage)
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Outcome measures
The eight IST outcome measures cover errors, latency,
total correct trials, mean number of boxes opened
per trial, and probability of the subject's decision
being correct based on the available evidence at
the time of the decision |
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SST (Stop
Signal Task)
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Overview
SST is a classic stop signal response inhibition
test, which uses staircase functions to generate
an estimate of stop signal reaction time.
This test gives a measure of an individuals
ability to inhibit a prepotent response.
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Administration time
Up to 20 minutes
Task
This test consists of two parts.
In the first part, the subject is introduced
to the press pad, and told to press the left hand
button when they see a left-pointing arrow, and
the right hand button when they see a right-pointing
arrow. There is one block of 16 trials for the
subject to practice this.
In the second part, the subject is told to continue
pressing the buttons on the press pad when they
see the arrows, as before, but, if they hear an
auditory signal (a beep), they should withhold
their response and not press the button.
Test modes
SST has one mode: clinical.
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Outcome measures
SST has 5 outcome measures, each of which can have
various options applied to it. The SST measures
cover direction errors, proportion of successful
stops, RT on GO trials, SSD (50%), SSRT |
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