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cognitive psychology, drug trials, cognitive testing, neuropsychology, cognitive research, computer-automated cognitive tests, computerised test battery, cognitive tests, CANTAB, CANTAB tests, CANTAB test battery, MCI, mild cognitive impairment, early detection of AD, Early detection of Alzheimer's Disease, clinical screening, screening for AD, screening for Alzheimer's Disease, dementia, Alzheimer's Disease, cognitive norms, Graded Naming Test, Expedio, CANTABexpedio, PAL on PDA, Reaction time, Memory clinic, Clinical trials, Memory loss, 21CFRpart11, neuroscience, neuropsychological assessment
 
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cognitive psychology, drug trials, cognitive testing, neuropsychology, cognitive research, computer-automated cognitive tests, computerised test battery, cognitive tests, CANTAB, CANTAB tests, CANTAB test battery, MCI, mild cognitive impairment, early detection of AD, Early detection of Alzheimer's Disease, clinical screening, screening for AD, screening for Alzheimer's Disease, dementia, Alzheimer's Disease, cognitive norms, Graded Naming Test, Expedio, CANTABexpedio, PAL on PDA, Reaction time, Memory clinic, Clinical trials, Memory loss, 21CFRpart11, neuroscience, neuropsychological assessment
cognitive psychology, drug trials, cognitive testing, neuropsychology, cognitive research, computer-automated cognitive tests, computerised test battery, cognitive tests, CANTAB, CANTAB tests, CANTAB test battery, MCI, mild cognitive impairment, early detection of AD, Early detection of Alzheimer's Disease, clinical screening, screening for AD, screening for Alzheimer's Disease, dementia, Alzheimer's Disease, cognitive norms, Graded Naming Test, Expedio, CANTABexpedio, PAL on PDA, Reaction time, Memory clinic, Clinical trials, Memory loss, 21CFRpart11, neuroscience, neuropsychological assessment
CANTAB - Executive function, working memory and planning tests
cognitive psychology, drug trials, cognitive testing, neuropsychology, cognitive research, computer-automated cognitive tests, computerised test battery, cognitive tests, CANTAB, CANTAB tests, CANTAB test battery, MCI, mild cognitive impairment, early detection of AD, Early detection of Alzheimer's Disease, clinical screening, screening for AD, screening for Alzheimer's Disease, dementia, Alzheimer's Disease, cognitive norms, Graded Naming Test, Expedio, CANTABexpedio, PAL on PDA, Reaction time, Memory clinic, Clinical trials, Memory loss, 21CFRpart11, neuroscience, neuropsychological assessment
 
These tests address executive function, working memory, and planning; all associated with the frontal area of the brain.

 

Intra-Extra Dimensional Set Shift (IED)


Overview

Intra-Extra Dimensional Set Shift is a test of rule acquisition and reversal. It features:
  • visual discrimination and attentional set formation
  • maintenance, shifting and flexibility of attention

This test is primarily sensitive to changes to the fronto-striatal areas of the brain.

This test is a computerised analogue of the Wisconsin Card Sorting test, and is sensitive to cognitive changes associated with schizophrenia, Parkinson's Disease, and dopaminergic dependent processes.

Administration time
Around 7 minutes, depending on level of impairment.

Task
Two artificial dimensions are used in the test:

  • colour-filled shapes
  • white lines

Simple stimuli are made up of just one of these dimensions, whereas compound stimuli are made up of both, namely white lines overlying colour-filled shapes. The subject starts by seeing two simple colour-filled shapes, and must learn which one is correct by touching it.

Feedback teaches the subject which stimulus is correct, and after six correct responses, the stimuli and/or rules are changed. These shifts are initially intra-dimensional (e.g. colour filled shapes remain the only relevant dimension), then later extra-dimensional (white lines become the only relevant dimension).

Subjects progress through the test by satisfying a set criterion of learning at each stage (6 consecutive correct responses). If at any stage the subject fails to reach this criterion after 50 trials, the test terminates.

Test modes
Clinical mode (for testing once); seven parallel modes (for repeated testing).

Outcome measures
This test has eighteen outcome measures, assessing errors, and numbers of trials and stages completed.
 

One Touch Stockings of Cambridge (OTS)


Overview
One Touch Stockings of Cambridge is a spatial planning test which gives a measure of frontal lobe function. OTS is a variant of the Stockings of Cambridge test (see below) and places greater demands on working memory as the subject has to visualise the solution
Click for an interactive demonstration
click for an interactive demonstration

Administration time
Around 10 minutes, depending on level of impairment

Task
As for SOC (Stockings of Cambridge), the subject is shown two displays containing three coloured balls. The displays are presented in such a way that they can easily be perceived as stacks of coloured balls held in stockings or socks suspended from a beam. This arrangement makes the 3-D concepts involved apparent to the subject, and fits with the verbal instructions.

There is a row of numbered boxes along the bottom of the screen. The test administrator first demonstrates to the subject how to use the balls in the lower display to copy the pattern in the upper display, and completes one demonstration problem, where the solution requires one move. The subject must then complete three further problems, one each of 2 moves, 3 moves and 4 moves.

Next the subject is shown further problems, and must work out in their head how many moves the solutions to these problems require, then touch the appropriate box at the bottom of the screen to indicate their response.

Test modes
OTS has four modes, with varying numbers of problems and boxes.

Outcome measures
OTS has 4 outcome measures - problems solved on first choice, mean choices to correct, mean latency to first choice and mean latency to correct. Each of these measures may be calculated for all problems, or for problems with a specified number of moves (1-move to 5 or 6 moves).
 

Stockings of Cambridge (SOC)


Overview
SOC is a spatial planning test which gives a measure of frontal lobe function.

Administration time
Around 10 minutes, depending on level of impairment

Task
The subject is shown two displays containing three coloured balls. The displays are presented in such a way that they can easily be perceived as stacks of coloured balls held in stockings or socks suspended from a beam. This arrangement makes the 3-D concepts involved apparent to the subject, and fits with the verbal instructions.

The subject must use the balls in the lower display to copy the pattern shown in the upper display. The balls may be moved one at a time by touching the required ball, then touching the position to which it should be moved. The time taken to complete the pattern and the number of moves required are taken as measures of the subject’s planning ability.

Test modes
Clinical mode

Outcome measures
This test has three outcome measures, including the number and percentage of correct trials and latency (speed of subject’s response).
 

Spatial Span (SSP)


Overview
Spatial Span assesses working memory capacity, and is a visuospatial analogue of the Digit Span test.

Administration time
Around 5 minutes, depending on level of impairment

Task
White squares are shown, some of which briefly change colour in a variable sequence. The subject must then touch the boxes which changed colour in the same order that they were displayed by the computer (for clinical mode) or in the reverse order (for reverse mode). The number of boxes increases from 2 at the start of the test to 9 at the end, and the sequence and colour are varied through the test.

Test modes
Two modes: clinical mode and reverse mode.

Outcome measures
This test has six outcome measures, covering span length (the longest sequence successfully recalled), errors, number of attempts and latency.
 

Spatial Working Memory (SWM)


Overview
SWM is a test of the subject’s ability to retain spatial information and to manipulate remembered items in working memory. It is a self-ordered task, which also assesses heuristic strategy. This test is a sensitive measure of frontal lobe and ‘executive’ dysfunction. It has been shown in recent studies that impaired performance on SWM emerges as a common factor in prepsychosis.

Administration time
Around 8 minutes, depending on level of impairment

Task
The test begins with a number of coloured squares (boxes) being shown on the screen. The aim of this test is that, by touching the boxes and using a process of elimination, the subject should find one blue ‘token’ in each of a number of boxes and use them to fill up an empty column on the right hand side of the screen. The number of boxes is gradually increased, until it is necessary to search a total of eight boxes. The colour and position of the boxes used are changed from trial to trial to discourage the use of stereotyped search strategies.

Test modes
Clinical mode.

Outcome measures
The twenty-four outcome measures for SWM include errors (touching boxes that have been found to be empty, and revisiting boxes which have already been found to contain a token), a measure of strategy, and latency measures.

 

cognitive psychology, drug trials, cognitive testing, neuropsychology, cognitive research, computer-automated cognitive tests, computerised test battery, cognitive tests, CANTAB, CANTAB tests, CANTAB test battery, MCI, mild cognitive impairment, early detection of AD, Early detection of Alzheimer's Disease, clinical screening, screening for AD, screening for Alzheimer's Disease, dementia, Alzheimer's Disease, cognitive norms, Graded Naming Test, Expedio, CANTABexpedio, PAL on PDA, Reaction time, Memory clinic, Clinical trials, Memory loss, 21CFRpart11, neuroscience, neuropsychological assessment
 
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